Ke ulu nei i kahi pale pale koko

Na nā limahana o Brain & Behaviour

Ua alakaʻi pū ʻia nā kānaka noiʻi e 2016 BBRF Young Investigator ʻo Ethan Lippmann, Ph.D., ua kūleʻa lākou i ke "kūkulu ʻana" i nā mea vaskular e hana e like me ka membrane pale koʻikoʻi o ka lolo, i kapa ʻia ka pale o ka lolo. Hana ka pale e like me kahi sieve wae, mālama i nā moleola nui me nā bacteria mai ka lolo a me ka wai o ka iwi, akā e ʻae i ka oxygen, glucose, a me nā mea ola ʻē aʻe e komo.

ʻO ka hana, hana ʻia ma Vanderbilt University a paʻi ʻia Pepeluali 14, 2019 ma Stem Cell Reports, pono e kōkua i ka wikiwiki o ka unuhi ʻana o nā manaʻo ʻepekema i ka noiʻi ʻana i ka lolo.

ʻOiai ua ulu nā moʻomeheu lolo-ʻelua dimensional i ka wā i hala, ʻo kēia ka manawa mua i hoʻokumu ʻia kahi hiʻohiʻona ʻekolu dimensional e hana e like me ka pale o ka lolo-kanaka. Ua ulu aʻe ke k modelkohu mai nā hunaola i lawe ʻia mai mai ka vasculature o ke kanaka i hoʻohuli ʻia e hoʻomohala hou ma ke ʻano he ʻano cell kūikawā ʻo ia ke kumu o ka pale o ka lolo. A laila ʻākoakoa lākou i loko o ka matrix dimensional ʻekolu e like me ka scaffold.

ʻO ke kaʻina hana re-polokalamu hou, i paionia i ka noiʻi lolo e nā mea hāʻawi BBRF a me nā mea ʻē aʻe i loko o nā makahiki he 10 i hala aku nei, ua kapa ʻia ʻo iPSC, ka mea i kū no ka ʻenehana “indur pluripotent stem cell” ʻenehana. Nui kāna mau noi ma nā lāʻau lapaʻau, ʻoiai i ka hoʻokumu ʻia ʻana o nā ʻano like ʻole o nā "organoids" - ola, ʻekolu dimensional moʻomeheu o nā hunaola i hoʻopili ʻia e hoʻomohala hou ʻia e like me nā ʻano cell i kikoʻī ʻia i nā ʻano kino like ʻole. Hoʻokahi ala hoʻohiki i mua i ka hoʻokolohua lāʻau a me ka noiʻi maʻi e waiho ana i ka hoʻokumu ʻana i nā hiʻohiʻona organoid o nā mea ola kanaka, e hoʻoholo ai i ka pono a me ka ikaika o nā lāʻau.

ʻOiai ua hoʻokolohua nā kānaka noiʻi me nā organoids lolo rudimentary, ke ʻano hana hou no ka hana hou ʻana i nā hale e hana i ke ʻano o ka pale o ka lolo-kanaka, inā hoʻokomo ʻia i loko o nā organoids o ka lolo, e hoʻokokoke i ka ʻepekema i ka hana ʻana i nā "lolo i kahi pā" ʻoiaʻiʻo kope i ka hanana a me ka hana o ka lolo kanaka maoli, a i ʻole nā ​​ʻāpana o lākou.

ʻO ke kope ʻana i ka pale endothelial i loko o ka organoids o ka lolo he koʻikoʻi, no ka mea, pono e pale ʻia ka lolo mai nā mea o ke koko.

Hoʻokumu ka pale o ka lolo-koko i nā "leaks" i kekahi mau maʻi, e like me kekahi mau maʻi neurological me ALS a me epilepsy. ʻOi aku ka permeable ke hiki i ka lī i ke kino i nā kiʻekiʻe kiʻekiʻe. ʻO kēia paha kekahi ala e komo ai nā mole mole i ka lolo a hoʻopili i ka hana maʻamau, e like me nā sclerosis he nui.